cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester
CAS No.:1346450-31-4
Molecular Formula:C₁₂H₁₈N₂O₃
Molecular Weight:238.287
Hs Code.:

Synonyms:cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

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Chemical Property of cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

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Technology Process of cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

There total 6 articles about cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1346450-08-5
cis/trans-ethyl 4-(chloro(hydroxyimino)methyl)cyclohexanecarboxylate

: 2208-07-3
ethyl acetimidate hydrochloride

: 1346450-31-4
cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 22.25h; Reflux;

Reference yield: 56.0%

: ethyl 4-(chloro(hydroxyimino)methyl)cyclohexanecarboxylate

: 2208-07-3
ethyl acetimidate hydrochloride

: 1346450-31-4
cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

Guidance literature:: ethyl 4-(chloro(hydroxyimino)methyl)cyclohexanecarboxylate; ethyl acetimidate hydrochloride; With triethylamine; In dichloromethane; for 22h; Reflux;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 13380-84-2
4-(hydroxymethyl)cyclohexane-1-carboxylic acid

: 1346450-31-4
cis/trans-4-(5-methyl-[1,2,4]oxadiazol-3-yl)cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -65 °C

2.2: Cooling

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 16 h / 20 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.17 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 22.25 h / 0 °C / Reflux

With N-chloro-succinimide; oxalyl dichloride; hydroxylamine hydrochloride; sodium acetate; dimethyl sulfoxide; triethylamine; sulfuric acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;