(4-(Aminomethyl)phenyl)(phenyl)methanone hydrochloride

Base Information

• Chemical Name: (4-(Aminomethyl)phenyl)(phenyl)methanone hydrochloride
• CAS No.: 24095-40-7
• Molecular Formula: C₁₄H₁₃NO*ClH
• Molecular Weight: 247.724
• Hs Code.: 2922399090
• European Community (EC) Number: 674-317-3
• DSSTox Substance ID: DTXSID00375442
• Mol file: 24095-40-7.mol

Synonyms:(4-(aminomethyl)phenyl)(phenyl)methanone hydrochloride;24095-40-7;4-Benzoyl benzylamine hydrochloride;4-benzoylbenzylamine hydrochloride;[4-(aminomethyl)phenyl]-phenylmethanone;hydrochloride;[4-(Aminomethyl)phenyl]phenyl-methanone HCl;4-(Aminomethyl)benzophenone hydrochloride;[4-(Aminomethyl)phenyl](phenyl)methanone hydrochloride;(4-benzoylphenyl)methanamine hydrochloride;[4-(aminomethyl)phenyl]-phenyl-methanone Hydrochloride;[4-(aminomethyl)phenyl]-phenylmethanone hydrochloride;SCHEMBL2450035;4-BENZOYLBENZYLAMINE HCL;4-(Aminomethyl)benzophenone HCl;DTXSID00375442;MFCD06245504;AKOS015847663;FS-5602;CS-0156559;FT-0659182;FT-0778193;(4-(aminomethyl)phenyl)(phenyl)methanone HCl;4-Benzoyl benzylamine hydrochloride, AldrichCPR;C78087;A817091;EN300-18527779;W-206874;(4-(aminomethyl)phenyl)(phenyl)methanonehydrochloride;Methanone,[4-(aminomethyl)phenyl]phenyl-, hydrochloride (9CI)

Chemical Property of (4-(Aminomethyl)phenyl)(phenyl)methanone hydrochloride

Chemical Property:

• Melting Point: 122-125oC
• Boiling Point: 97-99/0.38mm
• PSA: 43.09000
• LogP: 3.87860
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Moisture Sensitive/Lachrymatory
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 247.0763918
• Heavy Atom Count: 17
• Complexity: 225

Purity/Quality:

98%min ^*data from raw suppliers

4-(Aminomethyl)benzophenone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,T,Xi
• Hazard Codes: C,T,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)CN.Cl

Technology Process of (4-(Aminomethyl)phenyl)(phenyl)methanone hydrochloride

There total 2 articles about (4-(Aminomethyl)phenyl)(phenyl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4-(azidomethyl)phenyl)(phenyl)methanone (94341-52-3) → 4-(aminomethyl)phenyl(phenyl)methanone hydrochloride (24095-40-7)

Guidance literature:

[4-(azidomethyl)phenyl](phenyl)methanone; With 1,3-diphenyl-disiloxane; triphenylphosphine; at 20 ℃; for 24h;

With water;

With hydrogenchloride; In 1,4-dioxane; chemoselective reaction;

DOI:10.1021/acs.joc.9b00831

Reference yield:

4-(bromomethyl)benzophenone (32752-54-8) → 4-(aminomethyl)phenyl(phenyl)methanone hydrochloride (24095-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / acetone; water / 23 °C

2.1: triphenylphosphine / 20 h / 110 °C / Green chemistry

2.2: Green chemistry

With sodium azide; triphenylphosphine; In water; acetone; 2.1: |Staudinger Azide Reduction;

DOI:10.1039/c8gc02136h

upstream raw materials:

(4-(azidomethyl)phenyl)(phenyl)methanone

4-(bromomethyl)benzophenone

Refernces

• 1、 Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin. "Sustainable organophosphorus-catalysed Staudinger reduction". supporting information. p. 4418 - 4422. Retrieved 2018/10/17.