N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

Base Information

Chemical Name:N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide
CAS No.:1260095-66-6
Molecular Formula:C₁₅H₁₃Br₂NO₃
Molecular Weight:415.081
Hs Code.:

Synonyms:N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

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Chemical Property of N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

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Technology Process of N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

There total 5 articles about N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1260095-62-2
N-(3,5-bis(methoxymethyl)phenyl)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamide

: 1260095-66-6
N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

Guidance literature:: N-(3,5-bis(methoxymethyl)phenyl)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamide; With hydrogen bromide; acetic acid; In dichloromethane; at 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane; pH=7;
DOI:10.1021/ja106076h

Reference yield:

: 99-12-7
5-nitro-m-xylene

: 1260095-66-6
N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

2.1: sodium

2.2: 2 h / Reflux

3.1: iron; sodium chloride / tetrahydrofuran; methanol; water / 3.5 h / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 48 h / 20 °C

5.1: hydrogen bromide; acetic acid / dichloromethane / 20 °C

5.2: pH 7

With N-Bromosuccinimide; hydrogen bromide; sodium; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium chloride; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja106076h

Reference yield:

: 1312109-80-0
1,3-bis(methoxymethyl)-5-nitrobenzene

: 1260095-66-6
N-(3,5-bis(bromomethyl)phenyl)-3,4-dihydroxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; sodium chloride / tetrahydrofuran; methanol; water / 3.5 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 48 h / 20 °C

3.1: hydrogen bromide; acetic acid / dichloromethane / 20 °C

3.2: pH 7

With hydrogen bromide; iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja106076h