diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:118267-62-2
Molecular Formula:C₁₉H₂₂FNO₄
Molecular Weight:347.386
Hs Code.:

Synonyms:diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 3 articles about diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-97-9
ethyl acetoacetate

: 446-52-6
2-Fluorobenzaldehyde

: 118267-62-2
diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With [Cp₂Zr(H₂O)₂]⁺[OSO₂C₄F₉]^-₂; ammonium acetate; In neat (no solvent); at 80 ℃; for 2.5h;
DOI:10.1016/j.jorganchem.2015.02.014

Reference yield: 75.0%

: 506-87-6,6721-33-1,10361-29-2
ammonium carbonate

: 141-97-9
ethyl acetoacetate

: 446-52-6
2-Fluorobenzaldehyde

: 118267-62-2
diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In water; at 80 ℃;
DOI:10.1016/j.ejmech.2015.03.018

Reference yield: 62.0%

: 141-97-9
ethyl acetoacetate

: 89-99-6
2-fluorobenzylamine

: 118267-62-2
diethyl 4-(2-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: 2-fluorobenzylamine; With fluorenone imine; In toluene; at 20 ℃; for 1h;

ethyl acetoacetate; With ammonium acetate; In toluene; for 48h; Reflux; Inert atmosphere;
DOI:10.1039/c9ob02163a