5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

Base Information

Chemical Name:5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene
CAS No.:267406-72-4
Molecular Formula:C₅₆H₆₉N₇O₆
Molecular Weight:936.207
Hs Code.:

Synonyms:5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

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Chemical Property of 5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

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Technology Process of 5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

There total 5 articles about 5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 267406-71-3
C₄₈H₅₉ClN₆O₆

: 267406-72-4
5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 67 ℃; for 48h;
DOI:10.1021/ja9936262

Reference yield:

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 267406-72-4
5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / NEt₃ / dimethylformamide / 3 h / 50 °C

2: DIPEA / tetrahydrofuran / 3 h / 0 °C

3: NH₃(g) / tetrahydrofuran / 2 h / 0 °C

4: DIPEA / tetrahydrofuran / 48 h / 67 °C

With ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Condensation / 2: Condensation / 3: Substitution / 4: Condensation;
DOI:10.1021/ja9936262

Reference yield:

: 156874-49-6,169436-70-8,950744-70-4,1078151-72-0
5,17-diamino-25,26,27,28-tetrakis(propyloxy)calix[4]arene

: 267406-72-4
5-N-[4-amino-6-(R)-1-phenylethylamino-1,3,5-triazin-2-yl]-amino-17-N-(tert-butoxycarbamino)25,26,27,28-tetrapropoxycalix[4]arene

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / NEt₃ / dimethylformamide / 3 h / 50 °C

2: DIPEA / tetrahydrofuran / 3 h / 0 °C

3: NH₃(g) / tetrahydrofuran / 2 h / 0 °C

4: DIPEA / tetrahydrofuran / 48 h / 67 °C

With ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Condensation / 2: Condensation / 3: Substitution / 4: Condensation;
DOI:10.1021/ja9936262