(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

Base Information

Chemical Name:(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine
CAS No.:294647-05-5
Molecular Formula:C₂₅H₃₀N₆O
Molecular Weight:430.553
Hs Code.:

Synonyms:(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

Chemical Property:

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Technology Process of (R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

There total 3 articles about (R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5856-63-3
(2R)-2-aminobutan-1-ol

: 294648-35-4
N-(biphenyl-4-ylmethyl)-2-chloro-9-isopropyl-9H-purin-6-amine

: 294647-05-5
(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

Guidance literature:: at 170 ℃; for 12h;
DOI:10.1021/ml3002083

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 294647-05-5
(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 15 - 20 °C

2: triethylamine / butan-1-ol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

3: 12 h / 170 °C

With potassium carbonate; triethylamine; In dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/ml3002083

Reference yield:

: 203436-45-7
2,6-dichloro-9-isopropyl-9H-purine

: 294647-05-5
(R)-2-(1-hydroxy-but-2-ylamino)-6-[4-(phenyl)phenylmethylamino]-9-iso-propylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / butan-1-ol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

2: 12 h / 170 °C

With triethylamine; In butan-1-ol;
DOI:10.1021/ml3002083