4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

Base Information

Chemical Name:4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol
CAS No.:406162-23-0
Molecular Formula:C₂₆H₂₀Cl₂N₄O₂
Molecular Weight:491.376
Hs Code.:

Synonyms:4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

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Chemical Property of 4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

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Technology Process of 4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

There total 3 articles about 4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 406162-22-9
(4-chloro-phenyl)-[4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(5-mercapto-4-methyl-4H-[1,2,4]triazol-3-yl)-methanol

: 406162-23-0
4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

Guidance literature:: With nitric acid; sodium nitrite; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmcl.2003.09.043

Reference yield:

: 406162-21-8
(4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone

: 406162-23-0
4-(3-chlorophenyl)-α-(4-chlorophenyl)-2-methoxy-α-(4-methyl-4H-1,2,4-triazol-3-yl)-6-quinolinemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / n-BuLi / tetrahydrofuran / 2.5 h / -70 - 0 °C

2: 61 percent / aq. NaNO₂; HNO₃ / tetrahydrofuran / 0.25 h / 20 °C

With n-butyllithium; nitric acid; sodium nitrite; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.09.043