2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester

Base Information

• Chemical Name: 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester
• CAS No.: 177033-57-7
• Molecular Formula: C₃₆H₁₄Cl₁₂O₈
• Molecular Weight: 999.938
• Mol file: 177033-57-7.mol

Synonyms:2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester

Chemical Property of 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester

There total 3 articles about 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2.2’-(1,4-phenylene)dimalonic acid (177033-56-6) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8) → 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester (177033-57-7)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2h;

DOI:10.1016/0040-4020(96)00183-4

Reference yield:

2-(4-bromophenyl)malonic acid diethyl ester (93139-85-6) → 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester (177033-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) t-BuOK, 2.) dichlorobis(triphenylphosphine)-palladium / 1.) 1,2-dimethoxyethane, 0 deg C, 10 min, 2.) 1,2-diethoxyethane, 70 deg C, 20 h

2: 74 percent / KOH / propan-2-ol; ethanol / 48 h / -8 °C

3: 88 percent / POCl₃ / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; potassium tert-butylate; trichlorophosphate; In ethanol; isopropyl alcohol;

DOI:10.1016/0040-4020(96)00183-4

Reference yield:

p-phenylene-bis-(diethyl malonate) (79815-73-9) → 2-{4-[Bis-(2,4,6-trichloro-phenoxycarbonyl)-methyl]-phenyl}-malonic acid bis-(2,4,6-trichloro-phenyl) ester (177033-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / KOH / propan-2-ol; ethanol / 48 h / -8 °C

2: 88 percent / POCl₃ / 2 h / 100 °C

With potassium hydroxide; trichlorophosphate; In ethanol; isopropyl alcohol;

DOI:10.1016/0040-4020(96)00183-4

upstream raw materials:

2.2’-(1,4-phenylene)dimalonic acid

2,4,6-Trichlorophenol

2-(4-bromophenyl)malonic acid diethyl ester

p-phenylene-bis-(diethyl malonate)