methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate
CAS No.:1562995-96-3
Molecular Formula:C₁₆H₁₁ClIN₃O
Molecular Weight:423.64
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Chemical Property of methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

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Technology Process of methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

There total 5 articles about methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1561771-96-7
2-chloro-6-cyclopropylbenzoyl chloride

: 1562995-96-3
methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 40 ℃; for 3h;

Reference yield:

: 1561771-92-3
2-chloro-6-cyclopropylbenzoic acid

: 1562995-96-3
methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 12 h / 0 - 25 °C

2: dmap; triethylamine / dichloromethane / 3 h / 40 °C

With dmap; oxalyl dichloride; triethylamine; In dichloromethane;

Reference yield:

: 685892-23-3
methyl 2-acetyl-6-chlorobenzoate

: 1562995-96-3
methyl 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine; potassium phosphate; palladium diacetate / toluene; water / Inert atmosphere

2: water; sodium hydroxide / water; ethanol / 14 h / 80 °C

3: oxalyl dichloride / dichloromethane / 12 h / 0 - 25 °C

4: dmap; triethylamine / dichloromethane / 3 h / 40 °C

With dmap; potassium phosphate; oxalyl dichloride; water; palladium diacetate; triethylamine; sodium hydroxide; tricyclohexylphosphine; In ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling;