methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate
CAS No.:1596367-44-0
Molecular Formula:C₃₃H₃₉NO₅
Molecular Weight:529.676
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

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Chemical Property of methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

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Technology Process of methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

There total 3 articles about methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1596367-28-0
1-(cyclobutylmethyl)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one

: 1596367-43-9
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methyl-3-trifluoromethanesulfonyloxy-phenyl]acetate

: 1596367-44-0
methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1596367-41-7
methyl 2-(tert-butoxy)-2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

: 1596367-44-0
methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / ethyl acetate / 36 h / 20 °C

2: triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 1596367-42-8
methyl 2-(tert-butoxy)-2-[2-(3 ,4-d ihydro-2H-1-benzopyran-6-yl)-3-hydroxy-6-methylphenyl]acetate

: 1596367-44-0
methyl 2-(tert-butoxy)-2-[3-(1-cyclobutylmethyl6-oxo-1,6-dihydro-pyridin-3-yl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water;