benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

Base Information

Chemical Name:benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate
CAS No.:122225-46-1
Molecular Formula:C₂₆H₃₃NO₇
Molecular Weight:471.551
Hs Code.:

Synonyms:benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

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Chemical Property of benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

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Technology Process of benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

There total 1 articles about benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122225-43-8
1-<(benzyloxy)carbonyl>-3,4-cis-bis(methoxymethoxy)pyrrolidine

: 122225-46-1
benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00169a024

Reference yield: 95.0%

: 122225-46-1
benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

: 122225-48-3
(2R)-2-benzyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 1h;
DOI:10.1021/jm00169a024

Reference yield:

: 122225-46-1
benzyl (2R)-2-benyl-3-<<3,4-cis-bis(methoxymethoxy)pyrrolidino>carbonyl>propionate

: 122224-83-3
(R)-2-Benzyl-4-((3R,4S)-3,4-bis-methoxymethoxy-pyrrolidin-1-yl)-N-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-4-oxo-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10percent Pd/C / methanol / 1 h

2: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00169a024