2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Base Information

Chemical Name:2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile
CAS No.:1430230-83-3
Molecular Formula:C₁₄H₁₇ClN₂O
Molecular Weight:264.755
Hs Code.:

Synonyms:2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Suppliers and Price of 2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

There total 8 articles about 2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-chloro-4-[[2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

: 1430230-83-3
2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

: 1430230-84-4
2-chloro-4-[[2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Guidance literature:: With CHIRALPAK AD-H; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: 1430230-83-3
2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

: 1430230-84-4
2-chloro-4-[[2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / -70 °C

1.2: 19.5 h / -70 - -5 °C

2.1: lithium carbonate / water; dimethyl sulfoxide / 28 h / 130 °C / Inert atmosphere; Sealed tube

3.1: CHIRALPAK? AD-H / isopropyl alcohol; n-heptane / Resolution of racemate

With n-butyllithium; lithium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; n-heptane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 693-89-0
1-methylcyclopent-1-ene

: 1430230-83-3
2-chloro-4-[[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino]-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

2: ammonium hydroxide / ethanol; water / 4 h / 90 °C

3: lithium carbonate / water; dimethyl sulfoxide / 48 h / 130 °C

4: Resolution of racemate

With ammonium hydroxide; lithium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01168