1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

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Chemical Name:1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one
CAS No.:93193-93-2
Molecular Formula:C₄₀H₄₂N₈O₈
Molecular Weight:762.822
Hs Code.:

1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

Synonyms:1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

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Chemical Property of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

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Technology Process of 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

There total 10 articles about 1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 93170-54-8
C₆₄H₉₈N₈O₈Si₄

: 93193-93-2
1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)91006-8

Reference yield:

: 76-83-5
trityl chloride

: 93193-93-2
1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / DMAP / pyridine / 1 h / 80 °C

2: 49 percent / o-chlorophenylphosphorodichloridate / pyridine

3: 52 percent / DBU / CH₂Cl₂

4: 60 percent / TBAF / tetrahydrofuran

With dmap; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-chlorophenyl dichlorophosphate; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1016/S0040-4039(01)91006-8

Reference yield:

: 64911-18-8
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-hydroxy-1H-pyrimidin-2-one

: 93193-93-2
1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-{2-[9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yloxy]-ethylamino}-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / o-chlorophenylphosphorodichloridate / pyridine

2: 96 percent / acetonitrile

3: 52 percent / DBU / CH₂Cl₂

4: 60 percent / TBAF / tetrahydrofuran

With tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-chlorophenyl dichlorophosphate; In tetrahydrofuran; pyridine; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(01)91006-8