chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester
• CAS No.: 819798-11-3
• Molecular Formula: C₂₉H₃₀ClFO₆
• Molecular Weight: 529.005
• Mol file: 819798-11-3.mol

Synonyms:chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester

Chemical Property of chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester

There total 2 articles about chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

phenyl 2,3,6-tri-O-benzyl-4-O-chloroacetyl-1-thio-β-D-galactopyranoside (819798-10-2) → chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester (819798-11-3)

Guidance literature:

With N-Bromosuccinimide; diethylamino-sulfur trifluoride; at -15 ℃; for 1h;

Reference yield:

chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3-yl ester → chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester (819798-11-3)

Guidance literature:

With diethylamino-sulfur trifluoride;

DOI:10.1002/anie.200600433

Reference yield: 55.0%

chloro-acetic acid 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-yl ester (819798-11-3) → 4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-ol (819798-12-4)

Guidance literature:

With thiourea; In pyridine; ethanol; at 80 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

phenyl 2,3,6-tri-O-benzyl-4-O-chloroacetyl-1-thio-β-D-galactopyranoside

Downstream raw materials:

4,5-bis-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran-3-ol