trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride

Base Information

• Chemical Name: trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride
• CAS No.: 76325-96-7
• Molecular Formula: C₈H₁₅NO₂*ClH
• Molecular Weight: 193.674
• European Community (EC) Number: 878-113-7
• DSSTox Substance ID: DTXSID10504125
• Mol file: 76325-96-7.mol

Synonyms:76325-96-7;trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride;2-(4-Aminocyclohexyl)acetic acid hydrochloride;109572-36-3;4-Amino-cyclohexaneacetic acid HCl;61367-39-3;cis-2-(4-aminocyclohexyl)acetic acid;hydrochloride;Cyclohexaneacetic acid, 4-amino-, hydrochloride, trans-;2-(4-aminocyclohexyl)acetic acid;TRANS-2-(4-AMINOCYCLOHEXYL)ACETIC ACID HCL;2-(cis-4-Aminocyclohexyl)acetic acid hydrochloride;2-((1r,4r)-4-Aminocyclohexyl)acetic acid hydrochloride;2-[(1r,4r)-4-aminocyclohexyl]acetic acid hydrochloride;trans-4-aminocyclohexylacetic acid hydrochloride;cis-2-(4-Aminocyclohexyl)acetic acid hydrochloride;SCHEMBL2993122;SCHEMBL2993124;SCHEMBL4276196;DTXSID10504125;MFCD16661170;MFCD16661180;AKOS016009141;AKOS040814320;DS-4504;SB13899;SB13900;PS-16770;SY343944;CS-0039017;CS-0100458;D76125;E83416;EN300-1213475;EN300-7400015;A865500;(4-Aminocyclohexyl)acetic acid--hydrogen chloride (1/1);2-[(1s,4s)-4-aminocyclohexyl]acetic acid hydrochloride;F2147-7933;Z1255418104;Z3243726577;rel-2-[(1r,4r)-4-aminocyclohexyl]acetic acid hydrochloride

Chemical Property of trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.0869564
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

97% ^*data from raw suppliers

trans-4-AminocyclohexaneaceticAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1CC(=O)O)N.Cl

Technology Process of trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride

There total 3 articles about trans-2-(4-Aminocyclohexyl)acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(cis-4-amino-cyclohexyl)-acetic acid (2952-01-4) → trans-4-aminocyclohexylacetic acid hydrochloride (76325-96-7,109572-36-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrogen; nickel; 1.) 130 deg C, 150 atm, 6 h;

DOI:10.1007/BF00951237

Reference yield:

trans-2-(4-aminocyclohexyl)acetic acid (2952-00-3) → trans-4-aminocyclohexylacetic acid hydrochloride (76325-96-7,109572-36-3)

Guidance literature:

With hydrogenchloride; In water; pH=5;

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → cis-4-aminocyclohexylacetic acid hydrochloride (61367-39-3,109572-36-3) + trans-4-aminocyclohexylacetic acid hydrochloride (76325-96-7,109572-36-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrogen; nickel; Yield given. Yields of byproduct given; 1.) H₂O, 130 deg C, 150 atm, 8 h;

DOI:10.1007/BF00951237

upstream raw materials:

4-nitrobenzeneacetic acid

(cis-4-amino-cyclohexyl)-acetic acid

trans-2-(4-aminocyclohexyl)acetic acid

Downstream raw materials:

N-phthalyl-trans-4-aminocyclohexylacetic acid

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride