tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

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Chemical Name:tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
CAS No.:1350918-43-2
Molecular Formula:C₃₄H₄₇FN₆O₄Si
Molecular Weight:650.869
Hs Code.:

tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Synonyms:tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

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Technology Process of tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

There total 8 articles about tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1350918-27-2
4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylic acid

: 1350918-42-1
tert-butyl 6-(2-amino-6-fluorophenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

: 1350918-43-2
tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1350918-43-2
tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1350918-43-2
tert-butyl 6-(2-fluoro-6-(4-(2-methylpyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)phenyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

4: sodium hydroxide; methanol / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With methanol; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;