(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

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Chemical Name:(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid
CAS No.:1268840-77-2
Molecular Formula:C₃₂H₃₃ClFN₃O₅
Molecular Weight:594.083
Hs Code.:

Synonyms:(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

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Chemical Property of (3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

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Technology Process of (3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

There total 8 articles about (3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268842-30-3
7-chloro-1-{1-[(3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-yl)carbonyl]piperidin-4-yl}-3,3-dimethyl-3,4-dihydro-1,5-naphthyridin-2(1H)-one

: 1268840-77-2
(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: 7-chloro-1-{1-[(3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-yl)carbonyl]piperidin-4-yl}-3,3-dimethyl-3,4-dihydro-1,5-naphthyridin-2(1H)-one; With sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; ethyl acetate; for 1h; cooling with ice;

With hydrogenchloride; sodium chlorite; In water; ethyl acetate; at 20 ℃; for 3h; pH=4;

Reference yield:

: 437764-46-0
benzyl 4-bromo-2-fluorobenzoate

: 1268840-77-2
(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Reflux

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C

3.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran

6.1: sodium hypochlorite; potassium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / ethyl acetate; water / 1 h / cooling with ice

6.2: 3 h / 20 °C / pH 4

With sodium hypochlorite; di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; 1.1: Suzuki-Miyaura reaction / 2.1: Mitsunobu reaction;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1268840-77-2
(3R)-3-[(4'-{[4-(7-chloro-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Reflux

3.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C

4.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran

7.1: sodium hypochlorite; potassium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / ethyl acetate; water / 1 h / cooling with ice

7.2: 3 h / 20 °C / pH 4

With sodium hypochlorite; di-tert-butyl-diazodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; 2.1: Suzuki-Miyaura reaction / 3.1: Mitsunobu reaction;