ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

Base Information

Chemical Name:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate
CAS No.:1235477-30-1
Molecular Formula:C₂₆H₂₇N₃O₇
Molecular Weight:493.516
Hs Code.:

Synonyms:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

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Chemical Property of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

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Technology Process of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

There total 5 articles about ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1235477-26-5
2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)acetic acid

: 949-67-7
L-tyrosine ethyl ester

: 1235477-30-1
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1007/s00706-010-0280-x

Reference yield: 60.0%

: 1235477-27-6
2,5-dioxo-1-pyrrolidinyl 2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)acetate

: 949-67-7
L-tyrosine ethyl ester

: 1235477-30-1
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

Guidance literature:: In tetrahydrofuran; for 8h; Reflux;
DOI:10.1007/s00706-010-0280-x

Reference yield:

: 1215293-89-2
3-benzyl-4-imino-2-oxo-1,2,3,4-tetrahydro-5-acetylpyrimidine

: 1235477-30-1
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]-3-(4-hydroxyphenyl)propionate

Guidance literature:: Multi-step reaction with 5 steps

1: water; acetic acid / 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 50 °C

4: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 0 - 5 °C

5: tetrahydrofuran / 8 h / Reflux

With water; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-010-0280-x