Technology Process of {2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(phenyl)methanol
There total 5 articles about {2,6-dichloro-4-[(phenylthio)methyl]pyridin-3-yl}(phenyl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bromobenzene;
With
magnesium;
In
tetrahydrofuran;
2,6-dichloro-4-[(phenylthio)methyl]nicotinaldehyde;
In
tetrahydrofuran;
at -78 - 0 ℃;
DOI:10.1021/jo0344081
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 62 percent / diisobutylaluminum hydride / CH2Cl2; toluene / -78 - 20 °C
2.1: Mg / tetrahydrofuran
2.2: 77 percent / tetrahydrofuran / -78 - 0 °C
With
diisobutylaluminium hydride; magnesium;
In
tetrahydrofuran; dichloromethane; toluene;
2.2: Grignard reaction;
DOI:10.1021/jo0344081
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 55 percent / potassium hydroxide / methanol / 7 h / Heating
2.1: 54 percent / phosphorus oxychloride / 9 h / 150 °C
3.1: 62 percent / diisobutylaluminum hydride / CH2Cl2; toluene / -78 - 20 °C
4.1: Mg / tetrahydrofuran
4.2: 77 percent / tetrahydrofuran / -78 - 0 °C
With
potassium hydroxide; diisobutylaluminium hydride; magnesium; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
4.2: Grignard reaction;
DOI:10.1021/jo0344081
