(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

Base Information

Chemical Name:(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride
CAS No.:111542-00-8
Molecular Formula:C₂₂H₂₇NO₄*ClH
Molecular Weight:405.922
Hs Code.:

Synonyms:(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

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Chemical Property of (S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

Chemical Property:

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Technology Process of (S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

There total 6 articles about (S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16503-46-1
2-bromo-4-phenyl butanoic acid

: 111542-00-8
(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 28percent aq. NH₃ / 168 h / Ambient temperature

3: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

4: SOCl₂

5: 27.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

6: ethanolic HCl

With hydrogenchloride; ammonium hydroxide; thionyl chloride; potassium carbonate; In water; dimethyl sulfoxide;
DOI:10.1021/jm00122a003

Reference yield:

: 1012-05-1
D,L-homophenylalanine

: 111542-00-8
(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

2: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

3: SOCl₂

4: 27.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

5: ethanolic HCl

With hydrogenchloride; thionyl chloride; potassium carbonate; In water; dimethyl sulfoxide;
DOI:10.1021/jm00122a003

Reference yield:

: 5440-40-4
2-(acetylamino)-4-phenylbutanoic acid

: 111542-00-8
(S)-2-((R)-1-Benzyloxycarbonyl-ethylamino)-4-phenyl-butyric acid ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

2: SOCl₂

3: 27.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

4: ethanolic HCl

With hydrogenchloride; thionyl chloride; potassium carbonate; In water; dimethyl sulfoxide;
DOI:10.1021/jm00122a003