2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester
CAS No.:188403-07-8
Molecular Formula:C₃₀H₂₉NO₆
Molecular Weight:499.563
Hs Code.:

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

There total 1 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 133464-46-7
(S)-2-[((9H-fluoren-9-yl)methoxy)carbonylamino]-5-(allyloxy)-5-oxopentanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 188403-07-8
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 22 ℃; for 6h;
DOI:10.1016/S0968-0896(96)00199-X

Reference yield:

: 188403-07-8
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

: 188403-09-0
2-decanoylamino-pentanedioic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMAP / 1.) CH₂Cl₂, 22 deg C, 24 h, 2.) CH₂Cl₂, 22 deg C, 2 h

2: 79.9 percent / Pd(PPh₃)4, Bu₃SnH / CH₂Cl₂ / 0.25 h

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In dichloromethane;
DOI:10.1016/S0968-0896(96)00199-X

Reference yield:

: 188403-07-8
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-benzyl ester

: (S)-4-[(2-Amino-ethyl)-methyl-carbamoyl]-2-decanoylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) DMAP / 1.) CH₂Cl₂, 22 deg C, 24 h, 2.) CH₂Cl₂, 22 deg C, 2 h

2: 79.9 percent / Pd(PPh₃)4, Bu₃SnH / CH₂Cl₂ / 0.25 h

3: 1.) Et₃N, 2.) benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate / 1.) CH₂Cl₂, 22 deg C, 5 min, 2.) CH₂Cl₂, 22 deg C, 10 min

4: Pd(PPh₃)4, Bu₃SnH / CH₂Cl₂; H₂O / 0.08 h / 22 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; water;
DOI:10.1016/S0968-0896(96)00199-X