(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Base Information

Chemical Name:(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate
CAS No.:182700-66-9
Molecular Formula:C₁₇H₂₂O₄S
Molecular Weight:322.425
Hs Code.:

Synonyms:(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Suppliers and Price of (1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

There total 14 articles about (1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1297322-20-3
(S)-5,5-dimethyl-4-oxocyclopent-2-enyl 4-toluenesulfonate

: diphenylisopropylsulfonium tetrafluoroborate

: 182700-66-9
(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Guidance literature:: diphenylisopropylsulfonium tetrafluoroborate; With lithium diisopropyl amide; In 1,2-dimethoxyethane; dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

(S)-5,5-dimethyl-4-oxocyclopent-2-enyl 4-toluenesulfonate; In 1,2-dimethoxyethane; dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0030-1258451

Reference yield: 90.0%

: 98-59-9
p-toluenesulfonyl chloride

: 148410-05-3
4-exo-hydroxy-3,3,6,6-tetramethylbicyclo[3.1.0]hexan-2-one

: 182700-66-9
(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/0040-4039(96)01410-4

Reference yield:

: 140624-24-4
Acetic acid (1S,2S,5R)-3,3,6,6-tetramethyl-4-oxo-bicyclo[3.1.0]hex-2-yl ester

: 182700-66-9
(1S,2S,5R)-3,3,6,6-tetramethyl-4-oxobicyclo[3.1.0]hexan-2-yl 4-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / methanol / 2 h / 20 °C

2: 90 percent / NEt₃ / CH₂Cl₂ / 1 h / 20 °C

With potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/0040-4039(96)01410-4