(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

Base Information

Chemical Name:(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate
CAS No.:1370022-17-5
Molecular Formula:C₁₈H₁₆O₅
Molecular Weight:312.322
Hs Code.:

Synonyms:(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

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Chemical Property of (3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

Chemical Property:

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Technology Process of (3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

There total 7 articles about (3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370022-14-2
C₁₇H₁₄O₅

: 18107-18-1
diazomethyl-trimethyl-silane

: 1370022-17-5
(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

Guidance literature:: With isopropyl alcohol; In diethyl ether; tert-butyl methyl ether; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol300453s

Reference yield:

: 82735-28-2
6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one

: 1370022-17-5
(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; zinc / 2 h / 20 °C / Reflux

2: sulfuric acid / 2.33 h / 20 °C

3: thionyl chloride / dichloromethane / 3 h / Reflux

4: 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 164 h / -15 °C / Inert atmosphere

5: isopropyl alcohol / diethyl ether; tert-butyl methyl ether / 1 h / 0 - 20 °C

With thionyl chloride; sulfuric acid; 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; acetic acid; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; zinc; In diethyl ether; dichloromethane; tert-butyl methyl ether;
DOI:10.1021/ol300453s

Reference yield:

: 4702-29-8
7-methoxy-1H-isochromene-1,3(4H)-dione

: 1370022-17-5
(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 164 h / -15 °C / Inert atmosphere

2: isopropyl alcohol / diethyl ether; tert-butyl methyl ether / 1 h / 0 - 20 °C

With 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; In diethyl ether; tert-butyl methyl ether;
DOI:10.1021/ol300453s