[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

Base Information

Chemical Name:[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone
CAS No.:403502-41-0
Molecular Formula:C₂₃H₂₈N₆O
Molecular Weight:404.515
Hs Code.:

[5-(2-amino-phenyl)-1<i>H</i>-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

Synonyms:[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

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Chemical Property of [5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

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Technology Process of [5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

There total 11 articles about [5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

: 403502-20-5
[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(2-nitro-phenyl)-1H-pyrrol-2-yl]-methanone

: 403502-41-0
[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 35 ℃; for 2h; under 1551.44 Torr;
DOI:10.1248/cpb.49.1406

Reference yield:

: 1466-88-2,66894-06-2
2-nitrocinnamic aldehyde

: 403502-41-0
[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 45.8 percent / NaOMe / methanol / 1.5 h / -10 - 20 °C

2: 76.2 percent / xylene / 0.25 h / Heating

3: 98.6 percent / 12 percent aq. KOH / 1 h / Heating

4: 62.4 percent / EDC / tetrahydrofuran / 12 h / 20 °C

5: 82.6 percent / H₂ / 10 percent Pd/C / ethanol / 2 h / 35 °C / 1551.44 Torr

With potassium hydroxide; hydrogen; sodium methylate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; xylene;
DOI:10.1248/cpb.49.1406

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 403502-41-0
[5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: 70.9 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2: Et₃N / CH₂Cl₂

3: H₂ / 10 percent Pd/C / methanol

4: NaCNBH₃ / methanol

5: CF₃COOH / CH₂Cl₂

6: 62.4 percent / EDC / tetrahydrofuran / 12 h / 20 °C

7: 82.6 percent / H₂ / 10 percent Pd/C / ethanol / 2 h / 35 °C / 1551.44 Torr

With hydrogen; sodium cyanoborohydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.49.1406