C₂₄H₂₄N₄O₃

Base Information

• Chemical Name: C₂₄H₂₄N₄O₃
• CAS No.: 1424869-61-3
• Molecular Formula: C₂₄H₂₄N₄O₃
• Molecular Weight: 416.48
• Mol file: 1424869-61-3.mol

Synonyms:C₂₄H₂₄N₄O₃

Chemical Property of C₂₄H₂₄N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₄N₄O₃

There total 7 articles about C₂₄H₂₄N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-(3-methoxy-5-prop-2-ynylphenyl)-2,3-dihydro-benzo[1,4]dioxine (1424869-85-1) + 2,4-diamino-6-ethyl-5-iodopyrimidine (514854-13-8) → C24H24N4O3 (1424869-61-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 65 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.01.008

Reference yield:

2.3-dihydro-1,4-benzodioxin-6-ylboronic acid (164014-95-3) → C24H24N4O3 (1424869-61-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 10 h / 80 °C / Inert atmosphere

2.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: mercury(II) diacetate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: potassium carbonate / methanol / 2 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; mercury(II) diacetate; potassium carbonate; caesium carbonate; triethylamine; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.2: |Wittig Olefination / 3.1: |Wittig Olefination / 4.1: |Wittig Olefination / 5.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.01.008

Reference yield:

3-bromo-5-methoxybenzaldehyde (262450-65-7) → C24H24N4O3 (1424869-61-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 10 h / 80 °C / Inert atmosphere

2.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: mercury(II) diacetate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: potassium carbonate / methanol / 2 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; mercury(II) diacetate; potassium carbonate; caesium carbonate; triethylamine; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling / 2.2: |Wittig Olefination / 3.1: |Wittig Olefination / 4.1: |Wittig Olefination / 5.1: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.01.008

upstream raw materials:

3-bromo-5-methoxybenzaldehyde

1-(3-bromo-5-methoxyphenyl)ethanone

2.3-dihydro-1,4-benzodioxin-6-ylboronic acid

6-(3-methoxy-5-prop-2-ynylphenyl)-2,3-dihydro-benzo[1,4]dioxine