trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Base Information

• Chemical Name: trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester
• CAS No.: 925463-71-4
• Molecular Formula: C₃₉H₃₈F₃N₃O₉S₂
• Molecular Weight: 813.873

Synonyms:trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Chemical Property of trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

There total 17 articles about trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-3-benzyloxy-phenol (925463-43-0) → trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester (925463-71-4)

Guidance literature:

Multi-step reaction with 14 steps

1: 84 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

2: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

3: CH₂Cl₂ / 15 h / 20 °C

4: 3.08 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.33 h / 0 °C

5: 94 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

6: osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

7: sodium periodate on silica gel / CH₂Cl₂ / 2 h

8: 3.00 g / sulfuric acid / tetrahydrofuran / 5 h

9: triethylamine / CH₂Cl₂ / 2 h

10: 1.79 g / trifluoromethanesulfonic acid / 1 h

11: lithium aluminum hydride / diethyl ether / 0 - 20 °C

12: 0.555 g / triethylamine; 4-dimethylaminopyridine / dioxane / 22 h

13: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

14: 0.414 g / potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 3: Diels-Alder reaction;

DOI:10.1021/jo062064j

Reference yield:

3-(benzyloxy)-4-nitrophenol (221615-94-7) → trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester (925463-71-4)

Guidance literature:

Multi-step reaction with 15 steps

1: sodium borohydride; nickel(II) chloride hexahydrate / tetrahydrofuran; methanol

2: 84 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

3: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

4: CH₂Cl₂ / 15 h / 20 °C

5: 3.08 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.33 h / 0 °C

6: 94 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

7: osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

8: sodium periodate on silica gel / CH₂Cl₂ / 2 h

9: 3.00 g / sulfuric acid / tetrahydrofuran / 5 h

10: triethylamine / CH₂Cl₂ / 2 h

11: 1.79 g / trifluoromethanesulfonic acid / 1 h

12: lithium aluminum hydride / diethyl ether / 0 - 20 °C

13: 0.555 g / triethylamine; 4-dimethylaminopyridine / dioxane / 22 h

14: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

15: 0.414 g / potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; 4: Diels-Alder reaction;

DOI:10.1021/jo062064j

Reference yield:

N-(2-benzyloxy-4-hydroxy-phenyl)-4-methyl-benzenesulfonamide (925463-44-1) → trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester (925463-71-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 96 percent / sodium periodate on silica gel / CH₂Cl₂ / 4 h

2: CH₂Cl₂ / 15 h / 20 °C

3: 3.08 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.33 h / 0 °C

4: 94 percent / sodium hydride / tetrahydrofuran / 0 - 20 °C

5: osmium tetroxide; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O

6: sodium periodate on silica gel / CH₂Cl₂ / 2 h

7: 3.00 g / sulfuric acid / tetrahydrofuran / 5 h

8: triethylamine / CH₂Cl₂ / 2 h

9: 1.79 g / trifluoromethanesulfonic acid / 1 h

10: lithium aluminum hydride / diethyl ether / 0 - 20 °C

11: 0.555 g / triethylamine; 4-dimethylaminopyridine / dioxane / 22 h

12: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

13: 0.414 g / potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 2: Diels-Alder reaction;

DOI:10.1021/jo062064j

upstream raw materials:

4-amino-3-benzyloxy-phenol

3-(benzyloxy)-4-nitrophenol

N-(2-benzyloxy-4-hydroxy-phenyl)-4-methyl-benzenesulfonamide

N-(2-benzyloxy-4-hydroxy-8-methyl-5,8-dihydro-naphthalen-1-yl)-4-methyl-benzenesulfonamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 925463-71-4 trifluoro-methanesulfonic acid 7-benzyloxy-4-{2-methoxymethoxy-3-[(1-methyl-1H-indole-2-carbonyl)-amino]-propyl}-3-methyl-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send