2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Base Information

Chemical Name:2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid
CAS No.:1268809-42-2
Molecular Formula:C₁₆H₂₁NO₆
Molecular Weight:323.346
Hs Code.:

Synonyms:2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

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Chemical Property of 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

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Technology Process of 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

There total 5 articles about 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 637337-20-3
2-[(2R)-2-[(1,1-dimethylethoxy)methyl]-3-[(4S)-4-(1-methylethyl)-2-oxo-5,5-diphenyloxazolidin-3-yl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione

: 1268809-42-2
2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Guidance literature:: 2-[(2R)-2-[(1,1-dimethylethoxy)methyl]-3-[(4S)-4-(1-methylethyl)-2-oxo-5,5-diphenyloxazolidin-3-yl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione; With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;

With water; lithium hydroxide; at 0 ℃; for 3h;
DOI:10.1002/hlca.201000409

Reference yield:

: 85-44-9
phthalic anhydride

: 1268809-42-2
2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 150 °C

2.1: oxalyl dichloride / dichloromethane

3.1: n-butyllithium / tetrahydrofuran / -20 °C

4.1: titanium tetrachloride; triethylamine

5.1: sulfuric acid / dichloromethane

6.1: dihydrogen peroxide / tetrahydrofuran; water / 0.08 h / 0 °C

6.2: 3 h / 0 °C

With n-butyllithium; oxalyl dichloride; sulfuric acid; dihydrogen peroxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.201000409

Reference yield:

: 17137-11-0
3-phthalimidopropionyl chloride

: 1268809-42-2
2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -20 °C

2.1: titanium tetrachloride; triethylamine

3.1: sulfuric acid / dichloromethane

4.1: dihydrogen peroxide / tetrahydrofuran; water / 0.08 h / 0 °C

4.2: 3 h / 0 °C

With n-butyllithium; sulfuric acid; dihydrogen peroxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.201000409