2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Base Information

• Chemical Name: 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid
• CAS No.: 1268809-42-2
• Molecular Formula: C₁₆H₂₁NO₆
• Molecular Weight: 323.346
• Mol file: 1268809-42-2.mol

Synonyms:2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Chemical Property of 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid

There total 5 articles about 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-[(2R)-2-[(1,1-dimethylethoxy)methyl]-3-[(4S)-4-(1-methylethyl)-2-oxo-5,5-diphenyloxazolidin-3-yl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione (637337-20-3) → 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid (1268809-42-2)

Guidance literature:

2-[(2R)-2-[(1,1-dimethylethoxy)methyl]-3-[(4S)-4-(1-methylethyl)-2-oxo-5,5-diphenyloxazolidin-3-yl]-3-oxopropyl]-1H-isoindole-1,3(2H)-dione; With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;

With water; lithium hydroxide; at 0 ℃; for 3h;

DOI:10.1002/hlca.201000409

Reference yield:

phthalic anhydride (85-44-9) → 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid (1268809-42-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 150 °C

2.1: oxalyl dichloride / dichloromethane

3.1: n-butyllithium / tetrahydrofuran / -20 °C

4.1: titanium tetrachloride; triethylamine

5.1: sulfuric acid / dichloromethane

6.1: dihydrogen peroxide / tetrahydrofuran; water / 0.08 h / 0 °C

6.2: 3 h / 0 °C

With n-butyllithium; oxalyl dichloride; sulfuric acid; dihydrogen peroxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/hlca.201000409

Reference yield:

3-phthalimidopropionyl chloride (17137-11-0) → 2-({[(2R)-2-carboxy-3-(1,1-dimethylethoxy)propyl]amino}carbonyl)benzoic acid (1268809-42-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / -20 °C

2.1: titanium tetrachloride; triethylamine

3.1: sulfuric acid / dichloromethane

4.1: dihydrogen peroxide / tetrahydrofuran; water / 0.08 h / 0 °C

4.2: 3 h / 0 °C

With n-butyllithium; sulfuric acid; dihydrogen peroxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/hlca.201000409

upstream raw materials:

phthalic anhydride

3-phthalimidopropionyl chloride

3-phthalimidopropanoic acid

(S)-4-(1-methylethyl)-3-<1-oxo-3-phthalimidopropyl>-5,5-diphenyloxazolidin-2-one

Downstream raw materials:

prop-2-en-1-yl (2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoate

(2R)-3-(1,1-dimethylethoxy)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]propanoic acid