tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

Base Information

Chemical Name:tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate
CAS No.:1282613-40-4
Molecular Formula:C₂₆H₄₀N₄O₃S
Molecular Weight:488.695
Hs Code.:

Synonyms:tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

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Chemical Property of tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

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Technology Process of tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

There total 7 articles about tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1282613-30-2
2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)acetaldehyde

: 138007-24-6
4-tert-butyl piperidine-4-carboxylate

: 1282613-40-4
tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

Guidance literature:: 2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)acetaldehyde; 4-tert-butyl piperidine-4-carboxylate; With acetic acid; In methanol; at 20 ℃; for 2h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;

Reference yield:

: 592-82-5
butyl isothiocyanate

: 1282613-40-4
tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / methanol / 10 - 15 °C

2.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

3.2: 2 h / 20 °C

4.1: acetic acid / methanol / 2 h / 20 °C

4.2: 2 h / 20 °C

With osmium(VIII) oxide; hydrazine hydrate; acetic acid; 4-methylmorpholine N-oxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; tert-butyl alcohol;

Reference yield:

: 6610-31-7
4-butyl-3-thiosemicarbazide

: 1282613-40-4
tert-butyl 1-(2-(4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)-2,6-dimethylphenoxy)ethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

2.2: 2 h / 20 °C

3.1: acetic acid / methanol / 2 h / 20 °C

3.2: 2 h / 20 °C

With osmium(VIII) oxide; acetic acid; 4-methylmorpholine N-oxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; tert-butyl alcohol;