Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate

Base Information

• Chemical Name: Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate
• CAS No.: 125827-90-9
• Molecular Formula: C₂₇H₂₈O₁₀
• Molecular Weight: 512.513
• Mol file: 125827-90-9.mol

Synonyms:Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate

Chemical Property of Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate

There total 1 articles about Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Ethyl (E)-3-<(2R*,3S*)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-3-hydroxymethylbenzofuran-5-yl>propenoate (125803-62-5,121620-07-3) + acetic anhydride (108-24-7) → Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate (125827-90-9)

Guidance literature:

With pyridine; for 12h; Ambient temperature;

Reference yield: 86.0%

Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate (125827-90-9) → Ethyl 3<(2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propionoate (125803-63-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

Ethyl (E)-3<2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propenoate (125827-90-9) → rac-cedrusin (125874-71-7,57687-37-3,75775-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / H₂ / 10percent Pd/C / methanol

2: 57 percent / LiAlH₄ / diethyl ether / 3 h

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

upstream raw materials:

Ethyl (E)-3-<(2R^*,3S^*)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-3-hydroxymethylbenzofuran-5-yl>propenoate

acetic anhydride

Downstream raw materials:

Ethyl 3<(2RS,3SR)-7-acetoxy-2-(4-acetoxy-3-methoxyphenyl)-3-acetoxymethyl)-2,3-dihydro-1-benzofuran-5-yl>-2-propionoate

rac-cedrusin