2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

Base Information

Chemical Name:2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one
CAS No.:1412898-19-1
Molecular Formula:C₂₈H₂₀F₃N₇O
Molecular Weight:527.508
Hs Code.:

Synonyms:2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

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Chemical Property of 2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

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Technology Process of 2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

There total 3 articles about 2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: C₁₇H₁₂ClF₃N₂O

: 17720-22-8
8-phenyl-9H-purin-6-amine

: 1412898-19-1
2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.0833333h; Microwave irradiation;
DOI:10.1016/j.tetlet.2012.08.137 DOI:10.1016/j.tetlet.2012.08.137

Reference yield:

: 4389-50-8
2-amino-6-methylbenzoic acid

: 1412898-19-1
2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: phosphorus trichloride / acetonitrile / 0.05 h / Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

With potassium carbonate; triethylamine; phosphorus trichloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.137 DOI:10.1016/j.tetlet.2012.08.137

Reference yield:

: 66232-40-4
2-[(chloroacetyl)amino]-6-methylbenzoic acid

: 1412898-19-1
2-(6-amino-8-phenylpurin-9-ylmethyl)-3-(2-trifluoromethylphenyl)-5-methyl-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus trichloride / acetonitrile / 0.05 h / Microwave irradiation

2: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 100 °C / Microwave irradiation

With potassium carbonate; phosphorus trichloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.137 DOI:10.1016/j.tetlet.2012.08.137