cis-1-benzyl-3,5-diacetoxypiperidine

Base Information

• Chemical Name: cis-1-benzyl-3,5-diacetoxypiperidine
• CAS No.: 913831-95-5
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 913831-95-5.mol

Synonyms:cis-1-benzyl-3,5-diacetoxypiperidine

Chemical Property of cis-1-benzyl-3,5-diacetoxypiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of cis-1-benzyl-3,5-diacetoxypiperidine

There total 1 articles about cis-1-benzyl-3,5-diacetoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isopropenyl acetate (108-22-5) + N-benzyl-3,5-dihydroxypiperidine (1792-78-5) → cis-1-benzyl-3,5-diacetoxypiperidine (913831-95-5) + trans-1-benzyl-3,5-diacetoxypiperidine

Guidance literature:

With Pseudomonas cepacia lipase Amano II; potassium tert-butylate; sodium carbonate; ruthenium-based catalyst; In tetrahydrofuran; toluene; at 50 ℃; for 72h;

DOI:10.1021/jo0615091

Reference yield:

cis-1-benzyl-3,5-diacetoxypiperidine (913831-95-5) → cis-1-benzylpiperidine-3,5-diol (913831-96-6)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Heating;

DOI:10.1021/jo0615091

Reference yield:

cis-1-benzyl-3,5-diacetoxypiperidine (913831-95-5) → (3R,5S)-1-benzyl-3-acetoxy-5-hydroxypiperidine

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / methanol / 1 h / Heating

2: 112 mg / Pseudomonas cepacia lipase Amano II / toluene / 4 h / 20 °C

With sodium hydroxide; Pseudomonas cepacia lipase Amano II; In methanol; toluene;

DOI:10.1021/jo0615091

upstream raw materials:

Isopropenyl acetate

N-benzyl-3,5-dihydroxypiperidine

Downstream raw materials:

cis-1-benzylpiperidine-3,5-diol