(+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride]

Base Information

• Chemical Name: (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride]
• CAS No.: 35051-65-1
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• Mol file: 35051-65-1.mol

Synonyms:(+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride]

Chemical Property of (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride]

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride]

There total 1 articles about (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride] (35051-65-1)

Guidance literature:

(S)-(+)-2-Amino-2-phenyl-propiopnsaeure, Me., HCl;

DOI:10.1002/hlca.19710540806

Reference yield: 85.0%

thiophosgene (463-71-8) + (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride] (35051-65-1) → (+)-[methyl (2S)-2-isothiocyanato-2-phenylpropionate] (252268-16-9)

Guidance literature:

With sodium bicarbonate; In hydrogen sulfide; water; toluene;

Reference yield: 81.0%

Z-Aib-OH (15030-72-5) + (+)-[methyl (2S)-2-amino-2-phenylpropionate hydrochloride] (35051-65-1) → Cbz-Aib-L-(α)Phg-OMe (711015-21-3)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jo040107v

Downstream raw materials:

Cbz-Aib-L-(α)Phg-OMe

Cbz-D-Pro-Aib-L-(αMe)Phg-OMe

(S)-3-Benzyloxycarbonylamino-N-((S)-1-methoxycarbonyl-1-phenyl-ethyl)-succinamic acid

(+)-[methyl (2S)-2-isothiocyanato-2-phenylpropionate]