N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide

Base Information

• Chemical Name: N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide
• CAS No.: 1164334-38-6
• Molecular Formula: C₁₆H₁₆ClNO
• Molecular Weight: 273.762
• Mol file: 1164334-38-6.mol

Synonyms:N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide

Chemical Property of N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide

There total 1 articles about N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylpropionyl chloride (25145-43-1,36240-11-6,59981-93-0,22414-26-2) + N-methyl-2-chloroaniline (932-32-1) → N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide (1164334-38-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield: 98.0%

N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide (1164334-38-6) → (3S)-1,3-dimethyl-3-phenyl-1,3-dihydro-indol-2-one

Guidance literature:

With (S,S)-1,3-bis-(2,2-dimethyl-1-o-methylphenylpropyl)imidazolium iodide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,2-dimethoxyethane; at 50 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201000031

Reference yield: 89.0%

N-(2-chlorophenyl)-N-methyl-2-phenylpropanoic acid amide (1164334-38-6) → 1,3-dimethyl-3-phenylindolin-2-one (42773-95-5)

Guidance literature:

With palladium diacetate; bis(1-adamantyl)phosphine oxide; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol901597d

upstream raw materials:

2-phenylpropionyl chloride

N-methyl-2-chloroaniline

Downstream raw materials:

1,3-dimethyl-3-phenylindolin-2-one