3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

Base Information

Chemical Name:3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester
CAS No.:1027236-77-6
Molecular Formula:C₁₈H₂₄N₂O₅S
Molecular Weight:380.465
Hs Code.:

Synonyms:3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

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Chemical Property of 3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

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Technology Process of 3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

There total 15 articles about 3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 1027236-77-6
3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaCH₂SOCH₃ / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1 h

2: diethyl ether; methanol

3: DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

4: H₂ / PtO₂ / methanol / 2585.7 Torr

5: NBS, Ph₃P / CH₂Cl₂ / 0.42 h / 0 - 20 °C

6: dimethylformamide / 2 h / 4A molecular sieves

7: 1.) NaOMe / 1.) MeOH, 10 min, 2.) MeOH, RT, 18 h

8: aq. KH₂PO₄ / diethyl ether / 18 h / 0 °C

With potassium dihydrogenphosphate; N-Bromosuccinimide; hydrogen; sodium methylate; diisobutylaluminium hydride; sodium methylsulfinylmethanide; triphenylphosphine; platinum(IV) oxide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960167w

Reference yield:

: 16424-56-9,81077-22-7,5771-67-5
(E/Z)-6-Phenylhex-5-enoic acid

: 1027236-77-6
3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; methanol

2: DIBAL-H / CH₂Cl₂ / 0.5 h / 0 °C

3: H₂ / PtO₂ / methanol / 2585.7 Torr

4: NBS, Ph₃P / CH₂Cl₂ / 0.42 h / 0 - 20 °C

5: 1.03 g / NO₂BF₄ / CH₂Cl₂ / 2 h / 0 °C

6: dimethylformamide / 2 h / 4A molecular sieves

7: 1.) NaOMe / 1.) MeOH, 10 min, 2.) MeOH, RT, 18 h

8: aq. KH₂PO₄ / diethyl ether / 18 h / 0 °C

With potassium dihydrogenphosphate; N-Bromosuccinimide; nitronium tetrafluoborate; hydrogen; sodium methylate; diisobutylaluminium hydride; triphenylphosphine; platinum(IV) oxide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960167w

Reference yield:

: 98078-15-0
6-phenylhex-5-en-1-ol

: 1027236-77-6
3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / PtO₂ / methanol / 2585.7 Torr

2: NBS, Ph₃P / CH₂Cl₂ / 0.42 h / 0 - 20 °C

3: 1.03 g / NO₂BF₄ / CH₂Cl₂ / 2 h / 0 °C

4: dimethylformamide / 2 h / 4A molecular sieves

5: 1.) NaOMe / 1.) MeOH, 10 min, 2.) MeOH, RT, 18 h

6: aq. KH₂PO₄ / diethyl ether / 18 h / 0 °C

With potassium dihydrogenphosphate; N-Bromosuccinimide; nitronium tetrafluoborate; hydrogen; sodium methylate; triphenylphosphine; platinum(IV) oxide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960167w