2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

Base Information

Chemical Name:2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide
CAS No.:186551-49-5
Molecular Formula:C₂₅H₂₄N₄O₅S
Molecular Weight:492.555
Hs Code.:

Synonyms:2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

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Chemical Property of 2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

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Technology Process of 2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

There total 9 articles about 2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₇N₃O₈S

: 186551-49-5
2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm990040h

Reference yield:

: 135-55-7
7-hydroxynaphthalene-2-sulfonic acid sodium salt

: 186551-49-5
2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaOH / ethanol / 16 h / 20 °C

2: 3.80 g / POCl₃; PCl₅ / 4 h / 120 °C

3: Et₃N / CH₂Cl₂ / 2 h

4: K₂CO₃ / acetone / 48 h

5: CF₃CO₂H / CH₂Cl₂ / 3 h

6: Et₃N / tetrahydrofuran / 0.25 h / -20 °C

7: 14.8 N aq. NH₃ / tetrahydrofuran / 16 h / 20 °C

With ammonium hydroxide; sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; acetone; 1: Methylation / 2: Chlorination / 3: Condensation / 4: Alkylation / 5: acidolysis / 6: Condensation / 7: ammonolysis;
DOI:10.1021/jm990040h

Reference yield:

: 56875-60-6
7-Methoxy-2-naphthalenesulfonyl chloride

: 186551-49-5
2-[[(S)-1-(3-Cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-(7-methoxy-naphthalene-2-sulfonyl)-amino]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: K₂CO₃ / acetone / 48 h

3: CF₃CO₂H / CH₂Cl₂ / 3 h

4: Et₃N / tetrahydrofuran / 0.25 h / -20 °C

5: 14.8 N aq. NH₃ / tetrahydrofuran / 16 h / 20 °C

With ammonium hydroxide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone; 1: Condensation / 2: Alkylation / 3: acidolysis / 4: Condensation / 5: ammonolysis;
DOI:10.1021/jm990040h