((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

Base Information

Chemical Name:((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))
CAS No.:1620824-74-9
Molecular Formula:C₃₀H₂₄Cl₄N₂O₁₂S₂
Molecular Weight:810.471
Hs Code.:

Synonyms:((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

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Chemical Property of ((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

Chemical Property:

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Technology Process of ((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

There total 15 articles about ((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone))) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1620824-71-6
((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)thiophenyl)methanone)))

: 1620824-74-9
((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: (4-(benzyloxy)-2-methoxyphenyl)(2-((tert-butyldimethylsilyloxy)methyl)-1′-tosyl-1′H-1,3′-bipyrrol-2′-yl)methanol

: 1620824-74-9
((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 30 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 50 °C

4.1: n-butyllithium / tetrahydrofuran; pentane / 0.5 h / -78 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3.5 h / 50 °C

6.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 12 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / -30 °C / Inert atmosphere

7.2: 3 h / 20 °C

8.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

9.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

10.1: potassium hydroxide / tetrahydrofuran; methanol / 0.25 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

12.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; n-butyllithium; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; boron tribromide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; pentane;

Reference yield:

: (4-(benzyloxy)-2-methoxyphenyl)(2-(hydroxymethyl)-1′-tosyl-1′H-1,3′-bipyrrol-2′-yl)methanone

: 1620824-74-9
((4,4',5,5'-tetrachloro-1'H-1,3'-bipyrrole-2,2′-diyl)bis(((2-hydroxy-4-(β-ethylacetate)sulfonylphenyl)methanone)))

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 50 °C

2.1: n-butyllithium / tetrahydrofuran; pentane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3.5 h / 50 °C

4.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 12 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / -30 °C / Inert atmosphere

5.2: 3 h / 20 °C

6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

8.1: potassium hydroxide / tetrahydrofuran; methanol / 0.25 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; n-butyllithium; palladium on activated charcoal; hydrogen; boron tribromide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; pentane;