methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate
CAS No.:1399843-38-9
Molecular Formula:C₂₀H₂₄BrFN₄O₃
Molecular Weight:467.338
Hs Code.:

Synonyms:methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

There total 5 articles about methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₃BrFN₃

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1399843-38-9
methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1399843-38-9
methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; sodium carbonate / 4 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: C₁₈H₂₁BrFNO₅

: 1399843-38-9
methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-fluoropyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With ammonium acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; toluene;