Technology Process of 1-[2-(2-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,2,2-trifluoro-ethanone
There total 2 articles about 1-[2-(2-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,2,2-trifluoro-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-allyl-N-(1-(2-bromophenyl)but-3-enyl)-2,2,2-trifluoroacetamide;
With
Grubbs catalyst first generation;
In
1,2-dichloro-ethane;
at 20 ℃;
for 1.5h;
Inert atmosphere;
With
lead(IV) tetraacetate;
In
1,2-dichloro-ethane;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2010.12.072
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere
1.2: 72 h / -78 - 20 °C / Inert atmosphere
2.1: Grubbs catalyst first generation / 1,2-dichloro-ethane / 1.5 h / 20 °C / Inert atmosphere
2.2: 16 h / 20 °C / Inert atmosphere
With
Grubbs catalyst first generation;
In
diethyl ether; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2010.12.072