Technology Process of 2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
There total 7 articles about 2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(2-chloro-4,5-dimethoxyphenyl)acetic acid;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 1h;
N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-2,2,2-trifluoro-N-methyl-acetamide hydrochloride;
With
triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxone(R); potassium chloride / water; acetonitrile / 1 h / 20 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
2.2: 1 h / 20 °C
With
oxone(R); oxalyl dichloride; potassium chloride;
N,N-dimethyl-formamide;
In
dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C
2.1: sodium hydride / methanol / 5 h
2.2: 1 h / Heating / reflux
2.3: 18 h
3.1: pyridine / 18 h / 20 °C
4.1: hydrogenchloride / methanol / 1 h / 60 °C
5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
5.2: 1 h / 20 °C
With
pyridine; hydrogenchloride; oxalyl dichloride; hydrogen; sodium hydride;
palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
methanol; dichloromethane;
