2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

Base Information

Chemical Name:2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone
CAS No.:1076690-71-5
Molecular Formula:C₂₀H₂₂ClN₃O₃
Molecular Weight:387.866
Hs Code.:

Synonyms:2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

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Chemical Property of 2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

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Technology Process of 2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

There total 7 articles about 2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 2898-63-7
2-(2-chloro-4,5-dimethoxyphenyl)acetic acid

: 1076690-99-7
N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-2,2,2-trifluoro-N-methyl-acetamide hydrochloride

: 1076690-71-5
2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: 2-(2-chloro-4,5-dimethoxyphenyl)acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-2,2,2-trifluoro-N-methyl-acetamide hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1076690-71-5
2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxone(R); potassium chloride / water; acetonitrile / 1 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 1 h / 20 °C

With oxone(R); oxalyl dichloride; potassium chloride; N,N-dimethyl-formamide; In dichloromethane; water; acetonitrile;

Reference yield:

: 1076690-81-7
3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-71-5
2-(2-chloro-4,5-dimethoxy-phenyl)-1-[3-(4-methylamino-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: sodium hydride / methanol / 5 h

2.2: 1 h / Heating / reflux

2.3: 18 h

3.1: pyridine / 18 h / 20 °C

4.1: hydrogenchloride / methanol / 1 h / 60 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

5.2: 1 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; hydrogen; sodium hydride; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; dichloromethane;