5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

Base Information

• Chemical Name: 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole
• CAS No.: 675147-97-4
• Molecular Formula: C₂₉H₃₃NO₄Si
• Molecular Weight: 487.671

Synonyms:5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

Chemical Property of 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

There total 3 articles about 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) + (4-methoxymethoxymethyl-2-phenyl-oxazol-5-yl)-methanol (675147-96-3) → 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole (675147-97-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1248/cpb.52.120

Reference yield:

4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole (441356-84-9) → 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole (675147-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C

1.2: 81 percent / diethyl ether; hexane / -78 - 20 °C

2.1: sodium borohydride / tetrahydrofuran; methanol / 0.5 h / 0 °C

3.1: 80.1 g / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.52.120

Reference yield:

4-methoxymethoxymethyl-2-phenyl-5-oxazolecarbaldehyde (441356-85-0) → 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole (675147-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride / tetrahydrofuran; methanol / 0.5 h / 0 °C

2: 80.1 g / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.52.120

upstream raw materials:

tert-butylchlorodiphenylsilane

(4-methoxymethoxymethyl-2-phenyl-oxazol-5-yl)-methanol

4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

4-methoxymethoxymethyl-2-phenyl-5-oxazolecarbaldehyde

Downstream raw materials:

[5-(tert-butyldiphenylsilyloxymethyl)-2-phenyl-1,3-oxazol-4-yl]methanol

methyl (E)-4-(4-{[5-(tert-butyldiphenylsilyloxymethyl)-2-phenyl-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-4-phenylbutanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 675147-97-4 5-(tert-butyldiphenylsilyloxymethyl)-4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send