trans-4'(4-n-Propylcyclohexyl)-3,4-difluor-1,1'-biphenyl(bch-3f.f)

Base Information

• Chemical Name: trans-4'(4-n-Propylcyclohexyl)-3,4-difluor-1,1'-biphenyl(bch-3f.f)
• CAS No.: 85312-59-0
• Molecular Formula: C21H24F2
• Molecular Weight: 314.4121
• Hs Code.: 29039990
• Mol file: 85312-59-0.mol

Synonyms:1,1'-Biphenyl,3,4-difluoro-4'-(4-propylcyclohexyl)-, trans-;1,1'-Biphenyl,3,4-difluoro-4'-(4-propylcyclohexyl)-, trans-;BCH 3F.F;BCH 3F.F;1,1'-Biphenyl,3,4-difluoro-4'-(trans-4-propylcyclohexyl)-;

Chemical Property of trans-4'(4-n-Propylcyclohexyl)-3,4-difluor-1,1'-biphenyl(bch-3f.f)

Chemical Property:

• Melting Point: 66-68℃
• Boiling Point: 404 ºC at 760 mmHg
• Flash Point: 167.6ºC
• PSA: 0.00000
• Density: 1.053 g/cm³
• LogP: 6.70570
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Sparingly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

3,4-Difluoro-4'-(trans-4-propylcyclohexyl)biphenyl >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4'(4-n-Propylcyclohexyl)-3,4-difluor-1,1'-biphenyl(bch-3f.f)

There total 6 articles about trans-4'(4-n-Propylcyclohexyl)-3,4-difluor-1,1'-biphenyl(bch-3f.f) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(trans-4-n-propylcyclohexyl)-4-bromobenzene (86579-53-5,167858-55-1) + (3,4-difluorophenyl)boronic acid (168267-41-2) → 3,4-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl (85312-59-0)

Guidance literature:

With 5%-palladium/activated carbon; potassium carbonate; In ethanol; water; at 80 ℃; for 0.5h;

DOI:10.1002/ejoc.201300334

Reference yield: 89.0%

1-bromo-3,4-difluorobenzene (348-61-8) + Dichloro-ethyl-[4-(4-propyl-cyclohexyl)-phenyl]-silane (182169-61-5) → 3,4-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl (85312-59-0)

Guidance literature:

With sodium hydroxide; palladium diacetate; triphenylphosphine; In benzene; at 80 ℃; for 62h;

DOI:10.1016/S0040-4039(96)02320-9

Reference yield: 88.0%

1-bromo-3,4-difluorobenzene (348-61-8) + 4-(trans-4-propylcyclohexyl)phenyltriethoxysilane → 3,4-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl (85312-59-0)

Guidance literature:

With potassium fluoride; propylene glycol; chloro-[2-(9-phenyl-1,10-phenanthrolin-2-yl)phenyl]palladium; In dichloromethane; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1002/asia.201901155

upstream raw materials:

4-chloro-1,2-difluorobenzene

Dichloro-ethyl-[4-(4-propyl-cyclohexyl)-phenyl]-silane

1-bromo-3,4-difluorobenzene

4-(trans-4-n-Propylcyclohexyl)phenyltrimethoxysilane

Refernces

• 1、 Liu, Chun,Rao, Xiaofeng,Zhang, Yixia,Li, Xinmin,Qiu, Jieshan,Jin, Zilin. "An aerobic and very fast Pd/C-catalyzed ligand-free and aqueous Suzuki reaction under mild conditions". supporting information. p. 4345 - 4350. Retrieved 2013/07/26.
• 2、 Shibata, Koichi,Miyazawa, Kazutoshi,Goto, Yasuyuki. "Preparation of functionalized biaryl compounds via cross-coupling reactions of aryltrialkoxysilanes with aryl bromides". . p. 1309 - 1310. Retrieved 2007/10/03.