Technology Process of (R)-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene
There total 1 articles about (R)-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole; dmap;
In
dichloromethane;
DOI:10.1021/jo971115x
- Guidance literature:
-
Multi-step reaction with 9 steps
1: Br2; Et3N / CH2Cl2
2: 510 mg / DBU / benzene / 20 °C
3: 55 percent / (MeCN)2PdCl2; AsPh3 / 1-methyl-pyrrolidin-2-one / 1.5 h / 80 °C
4: 98 percent / TBAF; AcOH / tetrahydrofuran
5: 88 percent / H2 / [Ir(COD)(py)PCy3]PF6 / CH2Cl2 / 3 h / 51714.8 Torr
6: 88 percent / diphenylphosphorylazide; DBU / tetrahydrofuran / 0 - 20 °C
7: H2 / Pd/C / ethanol / 1 h
8: K2CO3 / acetonitrile / 2 h / Heating
9: 10 mg / LiAlH(OMe)3 / tetrahydrofuran / 40 h / Heating
With
diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; hydrogen; bromine; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium (hydro)trimethoxyaluminate; triethylamine;
dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; Crabtree's catalyst; triphenyl-arsane;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; acetonitrile; benzene;
1: Bromination / 2: Dehydrobromination / 3: Arylation / 4: Substitution / 5: Catalytic hydrogenation / 6: Substitution / 7: Catalytic hydrogenation / 8: Substitution / 9: Reduction;
DOI:10.1016/S0040-4020(99)00456-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Br2, Et3N / CH2Cl2 / 0 °C
2: DBU / benzene
3: 55 percent / (MeCN)2PdCl2, AsPh3, NMP / 1.5 h / 80 °C
4: 100 percent / TBAF, AcOH / tetrahydrofuran / 72 h
5: 88 percent / H2, 3>PF6 / CH2Cl2 / 51714.8 Torr
6: 100 percent / activated MnO2 / CHCl3
With
1-methyl-pyrrolidin-2-one; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); (η4-1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate; triphenyl-arsane; tetrabutyl ammonium fluoride; hydrogen; bromine; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane; chloroform; benzene;
DOI:10.1021/jo971115x