(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

Base Information

Chemical Name:(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol
CAS No.:205943-27-7
Molecular Formula:C₂₅H₄₃NO₃
Molecular Weight:405.621
Hs Code.:

Synonyms:(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

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Chemical Property of (1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

Chemical Property:

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Technology Process of (1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

There total 8 articles about (1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50388-51-7
methyl 5,5-dimethyl-2-oxo-cyclohexanecarboxylate

: 205943-27-7
(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) lithium diisopropylamide / 1.) THF, hexanes, 0 deg C, 20 min, 2.) THF, hexanes, room temperature, overnight

2: cerium(III) chloride heptahydrate, sodium borohydride / methanol

3: 99 percent / imidazole / dimethylformamide / Ambient temperature

4: 100 percent / diisobutylaluminum hydride / toluene / 2 h / -78 °C

5: 93 percent / triethylamine, sulfur trioxide-pyridine complex / dimethylsulfoxide; CH₂Cl₂ / 1.5 h / Ambient temperature

6: 1.) titanium(IV) isopropoxide, 2.) sodium cyanoborohydride / 1.) room temperature, 2 h, 2.) ethanol, 20 h

7: 19.3 mg / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

With 1H-imidazole; titanium(IV) isopropylate; sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo971935+

Reference yield:

: 4255-62-3
4,4-dimethylcyclohexane-1-one

: 205943-27-7
(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / sodium hydride / tetrahydrofuran / 2 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, hexanes, 0 deg C, 20 min, 2.) THF, hexanes, room temperature, overnight

3: cerium(III) chloride heptahydrate, sodium borohydride / methanol

4: 99 percent / imidazole / dimethylformamide / Ambient temperature

5: 100 percent / diisobutylaluminum hydride / toluene / 2 h / -78 °C

6: 93 percent / triethylamine, sulfur trioxide-pyridine complex / dimethylsulfoxide; CH₂Cl₂ / 1.5 h / Ambient temperature

7: 1.) titanium(IV) isopropoxide, 2.) sodium cyanoborohydride / 1.) room temperature, 2 h, 2.) ethanol, 20 h

8: 19.3 mg / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

With 1H-imidazole; titanium(IV) isopropylate; sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo971935+

Reference yield:

: 3-Benzyloxymethyl-5,5-dimethyl-2-oxo-cyclohexanecarboxylic acid methyl ester

: 205943-27-7
(1R,2R,6S)-2-Benzyloxymethyl-6-{[((R)-2-hydroxymethyl-3,3-dimethyl-butyl)-methyl-amino]-methyl}-4,4-dimethyl-cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1: cerium(III) chloride heptahydrate, sodium borohydride / methanol

2: 99 percent / imidazole / dimethylformamide / Ambient temperature

3: 100 percent / diisobutylaluminum hydride / toluene / 2 h / -78 °C

4: 93 percent / triethylamine, sulfur trioxide-pyridine complex / dimethylsulfoxide; CH₂Cl₂ / 1.5 h / Ambient temperature

5: 1.) titanium(IV) isopropoxide, 2.) sodium cyanoborohydride / 1.) room temperature, 2 h, 2.) ethanol, 20 h

6: 19.3 mg / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

With 1H-imidazole; titanium(IV) isopropylate; sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo971935+