(3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

Base Information

Chemical Name:(3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine
CAS No.:1354049-03-8
Molecular Formula:C₂₃H₂₅NO₅S
Molecular Weight:427.521
Hs Code.:

Synonyms:(3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

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Chemical Property of (3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

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Technology Process of (3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

There total 2 articles about (3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 21985-04-6
3-phenyl-1-(2-thienyl)-2-propyn-1-one

: 120138-99-0
methyl 6-azido-6-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside

: 1354049-03-8
(3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

Guidance literature:: With tributylphosphine; In toluene; at 20 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1260218

Reference yield:

: 66224-56-4
methyl 6-azido-6-deoxy-α-D-mannopyranoside

: 1354049-03-8
(3aS,4S,5aR,11aR,11bS)-4-methoxy-2,2-dimethyl-10-phenyl-8-(2-thienyl)-3a,4,5a,6,11a,11b-hexahydro[1,3]dioxolo[4,5]pyrano[3,2-b][1,5]oxazocine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / acetone / 18 h / 20 °C / Inert atmosphere

2: tributylphosphine / toluene / 20 °C / Inert atmosphere

With tributylphosphine; toluene-4-sulfonic acid; In acetone; toluene;
DOI:10.1055/s-0030-1260218