(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Base Information

Chemical Name:(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol
CAS No.:479633-94-8
Molecular Formula:C₃₀H₄₆O₅Si
Molecular Weight:514.778
Hs Code.:

Synonyms:(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Suppliers and Price of (2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

There total 15 articles about (2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 479633-93-7
(2R,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propionic acid benzyl ester

: 479633-94-8
(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1039/b205487f

Reference yield:

: 139976-21-9
2-bromo-6-hydroxy-4-methylbenzaldehyde

: 479633-94-8
(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Guidance literature:: Multi-step reaction with 15 steps

1: 79 percent / NaH / dimethylformamide / 2 h

2: 66 percent / decahydronaphthalene / 7 h / 200 °C

3: 83 percent / PhI(OAc)2 / 12 h

4: 70 percent / Zn; AcOH / 7 h

5: 92 percent / K₂CO₃ / dimethylformamide / 12 h

6: 97 percent / TsOH*H₂O; 4 Angstroem molecular sieves / methanol / 12 h / Heating

7: 95 percent / OsO₄; aq. NaIO₄ / CCl₄; 2-methyl-propan-2-ol / 1.5 h

8: 95 percent / NaBH₄ / methanol / 1.5 h / 0 °C

9: 92 percent / NaH / tetrahydrofuran / 12 h

10: 95 percent / Amberlite IR-120 / acetone; H₂O / 12 h

11: 66 percent / CuI / Pd(PPh₃)4 / toluene / 40 h / Heating

12: 78 percent / Bu₂BOSO₂CF₃

13: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

14: 89 percent / tetrahydrofuran / 6 h / 0 °C

15: 89 percent / DIBALH / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; copper(l) iodide; osmium(VIII) oxide; Amberlite IR-120; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; decalin; tert-butyl alcohol; 2: Claisen rearrangement / 11: Stille coupling;
DOI:10.1039/b205487f

Reference yield:

: 479633-77-7
2-allyloxy-6-bromo-4-methylbenzaldehyde

: 479633-94-8
(2S,3S)-3-[3-(2-Benzyloxy-ethyl)-2,5-dimethoxy-4-methyl-6-vinyl-phenyl]-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propan-1-ol

Guidance literature:: Multi-step reaction with 14 steps

1: 66 percent / decahydronaphthalene / 7 h / 200 °C

2: 83 percent / PhI(OAc)2 / 12 h

3: 70 percent / Zn; AcOH / 7 h

4: 92 percent / K₂CO₃ / dimethylformamide / 12 h

5: 97 percent / TsOH*H₂O; 4 Angstroem molecular sieves / methanol / 12 h / Heating

6: 95 percent / OsO₄; aq. NaIO₄ / CCl₄; 2-methyl-propan-2-ol / 1.5 h

7: 95 percent / NaBH₄ / methanol / 1.5 h / 0 °C

8: 92 percent / NaH / tetrahydrofuran / 12 h

9: 95 percent / Amberlite IR-120 / acetone; H₂O / 12 h

10: 66 percent / CuI / Pd(PPh₃)4 / toluene / 40 h / Heating

11: 78 percent / Bu₂BOSO₂CF₃

12: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

13: 89 percent / tetrahydrofuran / 6 h / 0 °C

14: 89 percent / DIBALH / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; copper(l) iodide; osmium(VIII) oxide; Amberlite IR-120; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; decalin; tert-butyl alcohol; 1: Claisen rearrangement / 10: Stille coupling;
DOI:10.1039/b205487f