C₂₆H₂₂F₂N₂O₃

Base Information

• Chemical Name: C₂₆H₂₂F₂N₂O₃
• CAS No.: 1417404-25-1
• Molecular Formula: C₂₆H₂₂F₂N₂O₃
• Molecular Weight: 448.469
• Mol file: 1417404-25-1.mol

Synonyms:C₂₆H₂₂F₂N₂O₃

Chemical Property of C₂₆H₂₂F₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₂F₂N₂O₃

There total 12 articles about C₂₆H₂₂F₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-7-[(morpholin-4-yl)carbonyl]-10,11-dihydrodibenzo[a,d]cyclohepten-5-one (1417403-98-5) + 2,4-difluorophenylamine (367-25-9,76563-56-9) → C26H22F2N2O3 (1417404-25-1)

Guidance literature:

With potassium tert-butylate; palladium diacetate; XPhos; In toluene; tert-butyl alcohol; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm301539x

Reference yield:

C16H12Cl2O3 → C26H22F2N2O3 (1417404-25-1)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 °C

2: thionyl chloride / dichloromethane / 1 h / Reflux

3: dichloromethane / 0 - 20 °C

4: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; potassium tert-butylate; palladium diacetate; XPhos; In dichloromethane; toluene; tert-butyl alcohol; 1: |Friedel-Crafts Acylation / 4: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm301539x

Reference yield:

C16H10Cl2O2 → C26H22F2N2O3 (1417404-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 2 h / 100 °C / Inert atmosphere

With potassium tert-butylate; palladium diacetate; XPhos; In dichloromethane; toluene; tert-butyl alcohol; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm301539x

upstream raw materials:

2,4-dicyanotoluene

4-methyl isophthalic acid

dimethyl 4-methylbenzene-1,3-dicarboxylate

1-chloro-3-(iodomethyl)benzene

Downstream raw materials:

8-((2,4-difluorophenyl)amino)-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxylic acid

C₂₂H₁₆F₂N₂O₂

C₂₃H₁₈F₂N₂O₂

C₃₀H₃₀F₂N₂O₂