3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester

Base Information

• Chemical Name: 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester
• CAS No.: 179632-86-1
• Molecular Formula: C₁₈H₈F₄N₂O₂S₂
• Molecular Weight: 424.399
• Mol file: 179632-86-1.mol

Synonyms:3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester

Chemical Property of 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester

There total 2 articles about 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + 3,4,5,6-tetrafluorophthaloyl dichloride (14900-74-4) → 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester (179632-86-1)

Guidance literature:

With sodium methylate; In toluene; at -78 ℃;

DOI:10.1021/jo9604402

Reference yield:

3,4,5,6-tetrafluorophthalic acid (652-03-9) → 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester (179632-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / PCl₅ / 2 h / 180 °C

2: 43 percent / NaOMe / toluene / -78 °C

With phosphorus pentachloride; sodium methylate; In toluene;

DOI:10.1021/jo9604402

Reference yield:

2-bromothiophene (1003-09-4) + 3,4,5,6-Tetrafluoro-benzene-1,2-dicarbothioic acid di-S-pyridin-2-yl ester (179632-86-1) → [2,3,4,5-Tetrafluoro-6-(thiophene-2-carbonyl)-phenyl]-thiophen-2-yl-methanone (187282-64-0)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) THF, 3.5 h, 2.) THF, 0 deg C, 30 min;

DOI:10.1021/jo9604402

upstream raw materials:

2-Sulfanylpyridine

3,4,5,6-tetrafluorophthaloyl dichloride

3,4,5,6-tetrafluorophthalic acid

Downstream raw materials:

[2,3,4,5-Tetrafluoro-6-(thiophene-2-carbonyl)-phenyl]-thiophen-2-yl-methanone