benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

Base Information

Chemical Name:benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride
CAS No.:1119252-47-9
Molecular Formula:C₁₈H₁₅F₄NO₄*ClH
Molecular Weight:421.776
Hs Code.:

Synonyms:benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

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Chemical Property of benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

Chemical Property:

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Technology Process of benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

There total 4 articles about benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1119253-07-4
C₂₃H₂₃F₄NO₆

: 1119252-47-9
benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

Guidance literature:: With hydrogenchloride; water; In ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmcl.2008.10.117

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 1119252-47-9
benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C

1.2: 2.5 h / 0 - 15 °C / Inert atmosphere

1.3: 1 h / 0 - 15 °C

2.1: potassium iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 61 h / -5 °C

3.1: hydrogenchloride / ethyl acetate / 1 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydrogencarbonate; potassium iodide; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 189580-34-5
Boc-L-ASP(Bzl)-BMK

: 1119252-47-9
benzyl (S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium iodide; sodium hydrogencarbonate / N,N-dimethyl-formamide / 61 h / -5 °C

2: hydrogenchloride / ethyl acetate / 1 h / 0 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium iodide; In ethyl acetate; N,N-dimethyl-formamide;