5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

Base Information

Chemical Name:5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine
CAS No.:1227148-01-7
Molecular Formula:C₁₉H₁₅F₃N₆O₂
Molecular Weight:416.362
Hs Code.:

Synonyms:5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

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Chemical Property of 5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

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Technology Process of 5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

There total 6 articles about 5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1227148-17-5
2-Azido-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine

: 1227148-01-7
5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

Guidance literature:: With tributylphosphine; In methanol; water; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 1085453-46-8
5-(5-methyl-1H-pyrazol-3-yl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

: 1227148-01-7
5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 0 - 45 °C

2: hydrazine hydrate / 56 h / 20 °C / Inert atmosphere; Reflux

3: hydrogenchloride; sodium nitrite / water / 5 h / 20 °C / Cooling with ice

4: tributylphosphine / water; methanol / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; tributylphosphine; potassium tert-butylate; hydrazine hydrate; sodium nitrite; In tetrahydrofuran; methanol; water;

Reference yield:

: N'-hydroxy-4-(trifluoromethoxy) benzene-1-carboximidamide

: 1227148-01-7
5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 - 140 °C

2: potassium tert-butylate / tetrahydrofuran / 0 - 45 °C

3: hydrazine hydrate / 56 h / 20 °C / Inert atmosphere; Reflux

4: hydrogenchloride; sodium nitrite / water / 5 h / 20 °C / Cooling with ice

5: tributylphosphine / water; methanol / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; tributylphosphine; potassium tert-butylate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;