7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

Base Information

• Chemical Name: 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• CAS No.: 512844-78-9
• Molecular Formula: C₂₀H₁₆N₆O
• Molecular Weight: 356.387
• Mol file: 512844-78-9.mol

Synonyms:7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

Chemical Property of 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

There total 4 articles about 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-N-(4-imino-1-phenethyl-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl)-benzamide → 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (512844-78-9)

Guidance literature:

In diphenylether; at 260 ℃; for 1.5h;

DOI:10.1021/jm021023m

Reference yield:

5-amino-4-cyano-1-(β-phenylethyl)pyrazole (159979-74-5) → 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (512844-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Heating

2: 2-methoxy-ethanol / 12 h / Heating

3: diphenyl ether / 1.5 h / 260 °C

In diphenylether; 2-methoxy-ethanol;

DOI:10.1021/jm021023m

Reference yield:

4-hydroxybenzoic acid hydrazide (5351-23-5) → 7-(2-phenylethyl)-2-(4-hydroxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (512844-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methoxy-ethanol / 12 h / Heating

2: diphenyl ether / 1.5 h / 260 °C

In diphenylether; 2-methoxy-ethanol;

DOI:10.1021/jm021023m

upstream raw materials:

4-hydroxybenzoic acid hydrazide

5-amino-4-cyano-1-(β-phenylethyl)pyrazole

N-(4-cyano-2-phenethyl-2H-pyrazol-3-yl)-formimidic acid ethyl ester

Downstream raw materials:

[4-(5-amino-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-phenoxy]-acetic acid ethyl ester

4-(5-amino-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-phenol

5-amino-1-(2-phenylethyl)-4-[3-(4-hydroxyphenyl)-1,2,4-triazolo-5-yl]pyrazole